Flavin-Dependent Halogenase and Method for Preparing Halogenated Indole Compounds Using the Same

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The present invention relates to a method for manufacturing halogenated indole compounds using a recombinant Flavin-dependent halogenase (MrFDH) derived from a microorganism of the genus Micromonospora rhodorangea. More particularly, the present invention relates to a method for an enzymatic manufacture of novel halogenated indole compounds having antagonist activity against melatonin receptors. The enzymatically biotransformed halogenated indole derivative compounds using the recombinant Flavin-dependent halogenase (MrFDH) according to the present invention exhibit enhanced binding to melatonin receptors and antitumor acitivity against uveal melanoma, thereby being a very useful medical composition for treating sleep disorders, insomnia related diseases, or a rare eye cancer such as the uveal melanoma.COPYRIGHT KIPO 2018