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The present invention relates to a physiologically active material complex, a production method thereof, and a cosmetic composition for skin whitening, winkle removal, and anti-aging functions, comprising the same. The present invention provides a complex of stably complexing a physiologically active material with a rare earth hydroxide of a layered structure, wherein the physiologically active material in the complex preserves long-term stability even at the high temperature of 50° C or higher, and side effects such as potential toxicity and irritation by maintaining pH at neutral are minimized, thereby being used in the cosmetic composition for skin whitening, winkle removal, and anti-aging functions, comprising the same.COPYRIGHT KIPO 2017