MODIFIED PROTEIN ENCODING SEQUENCES HAVING INCREASED RARE HEXAMER CONTENT

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This invention provides a modified protein encoding sequence containing nucleotide substitutions at multiple locations in the protein encoding sequence, wherein the substitutions introduce rare hexamers. These hexamers may be Frame Dependent, or depleted in only the reading frame, or Frame Independent, or depleted in all three frames. Modified protein encoding sequences of the present invention may include modified viruses useful for vaccines.