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The present invention relates to an innate immunity-enhancing and anti-viral pharmaceutical composition comprising an extract of Hovenia dulcis Thunb. as an active ingredient, an innate immunity-enhancing and anti-viral health-aid food comprising an extract of Hovenia dulcis Thunb. as an active ingredient, and an innate immunity-enhancing and anti-viral feed composition comprising an extract of Hovenia dulcis Thunb. as an active ingredient. The present invention also relates to a method for enhancing innate immunity and anti-viral activities of animals, which comprises administering an extract of Hovenia dulcis Thunb. to non-human animals in need thereof. The innate immunity-enhancing and anti-viral pharmaceutical composition comprising an extract of Hovenia dulcis Thunb. according to the present invention shows an anti-viral activity and an effect enhancing innate immunity. Thus, the composition can be used for preventing and treating bacterial and viral infection diseases, and can be utilized widely for a pharmaceutical or health-aid food for enhancing and controlling immunity of an immuno-depressed or immuno-suppressed patient and for an innate immunity-enhancing and anti-viral feed for reinforcing the resistance of an animal against diseases. In addition, the innate immunity-enhancing and anti-viral composition according to the present invention causes little toxicity and side-effect, and thus can be used safely for a long administration period for the purpose of prevention.(a) 12 hours after infection(b) 24 hours after infection(C1, C2, C3) Hovenia dulcis Thunb./PR8-GFPCOPYRIGHT KIPO 2017