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METHOD OF PRODUCING LUTETIUM AND GADOLINIUM COMPLEXES WITH TETRABENZOPORPHYRIN

2025-06-19 18:284030下载
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FIELD : chemistry. SUBSTANCE : invention relates to method of producing lutetium and gadolinium complexes with tetrabenzoporphyrin. Method involves reaction of phthalimide with zinc acetate at 230-240°C for 20-30 minutes. Obtained 1-[(oxo-1H-isoindol-3-yl)methylene]-isoindoline-3-on is melted with rare-earth element salt and sodium acetate trihydrate at temperature 350-360°C for 40-50 minutes. End products are separated and purified by chromatography. EFFECT : technical result consists in reduced number of steps, increased output of end products and high degree of their purity. 1 cl, 4 dwg, 3 tbl, 2 ex


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