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Methods and systems biomedical application of up conversion nanoparticles. Co-doped cerium oxide nanoparticles were synthesized by precipitation technique. Up conversion nano cerias are biocompatible as a biomarker with antioxidant properties. Up conversion nano cerias interact in a cell specific manner showing catalase mimetic activity. With suitable surface targeting ligands, up conversion nano cerias can be used for site selective drug delivery for the treatment of diseases like cancer.