Examination methods of the bio-marker of allele

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According to the present invention, in order to enhance biomarker searching and discovering power, continuous variables used when defining nucleotide polymorphism are used to select and rank disease variation markers based on comparison analysis methods (allele square value difference, allele depth tangent difference, allele absolute value difference, geometric allele difference, statistical allele difference, and allele imbalance proportion), the weighted value with respect to the locus function, or the like, followed by reverse classification, thereby improving the sensitivity of discovering genome biomarkers corresponding various cancers, drug resistance of cancers, rare diseases, chronic diseases, and disease risks and phenotypes of normal persons, when compared with existing methods.