METHODS OF TREATING AUTOIMMUNE DISEASES

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PROBLEM TO BE SOLVED : To provide a potential therapeutic agent that may ameliorate certain autoimmune diseases, including multiple sclerosis and graft-versus-host disease, and improve kidney function and survival rates under the autoimmune diseases. SOLUTION : A process includes : depleting circulating lymphocytes in a mammal by administering anti-thymocyte antibody; and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-β and/or another agent that promotes expansion of regulatory T cells. COPYRIGHT : (C)2014, JPO&INPIT