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Inorganic doped nanoparticles based on calcium fluoride, suitable for multimodal imaging in diagnostic medicine, characterized in that a) they are doped with at least one rare earth ion, selected from Eu 3 +, 3 + 3 + Sm Tb, Dy 3 +, 3 + Yb, He 3 +, 3 + and/or a combination of these ions and b Tm) with a 3 + or them with Gd
ion combination
, 2 + 3 + plus Ba selected from Fe, Gd 3 + 3 + plus Fe, Gd 3 + 3 + 2 + 3 + plus Fe plus Ba 2 + plus Ba or Gd are doped and c) at least 95 mol % of the fluoride ions are present anions.