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The present invention relates to an amplifying optical fiber having a central core and an optical cladding surrounding the central core, wherein the central core is based on a silica matrix comprising nanoparticles, which nanoparticles are composed of a matrix material comprising doping ions of at least one rare earth element. The matrix of the nanoparticle is chosen to favor rare earth solubility and dispersion and to favor the amplification process. In addition, the present invention relates to an optical amplifier and an optical laser comprising the present optical fiber. In addition, the invention relates to a method of preparing nanoparticles in an aqueous solution having a predetermined pH, a method of manufacturing the present optical fiber comprising a heat treatment step to eliminate residual water and strengthen the nanoparticles, and uses of said optical fiber.