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METHOD OF PRODUCING 3-TRIFLUOROMETHYL CHALCONES

2025-06-22 23:172580下载
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FIELD : chemistry. SUBSTANCE : invention relates to an improved method of producing a compound of formula , where Z is optionally substituted phenyl and Q is phenyl or 1-naphthalenyl, each optionally substituted. The method involves distillation of water from a mixture containing a compound of formula , a compound of formula , a base containing at least one compound selected from a group comprising alkali-earth metal hydroxides of formula 4 M(OH)2, where M is Ca, Sr or Ba, alkali metal carbonates of formula 4a (M1)2CO3 , where M1 is Li, Na or K, 1, 5-diazabicyclo[4, 3.0]non-5-ene and 1, 8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. The invention also relates to a method of producing a compound of formula 2, a method of producing a compound of formula from a compound of formula 1 and a compound of formula 2. EFFECT : method enables to obtain a product with high output. 20 cl, 15 tbl, 8 ex


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