PYRIMIDINE DERIVATIVES AS ALK-5 INHIBITORS

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FIELD : chemistry.SUBSTANCE : invention relates to novel pyrimidine derivatives of formula (I) in free form or in form of a pharmaceutically acceptable salt or solvate, which are useful in treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders and other diseases which are mediated by activity of the ALK-5 receptor or ALK-4 receptor. The invention also relates to a method of producing compounds of formula (I) and pharmaceutical compositions. In formula, T is a pyridin-2-yl which is optionally substituted in one position with R; Tis a pyridinyl which is optionally substituted in one or two positions with R, R, R, C-C-alkoxy group, C-C-alkoxycarbonyl or cyano group; and Rand Rare independently hydrogen; C-C-alkyl, optionally substituted in one, two or three positions with R; C-C-cycloalkyl, which is optionally substituted in one or two positions with a hydroxy group, amino group, C-C-alkyl, C-C-alkoxy group, halogen, cyano group, oxo group, carboxy group or nitro group; or C-C-aryl, optionally substituted in one, two or three positions with a halogen, hydroxy group, amino group, cyano group, oxo group, carboxy group, nitro group or R; Ris C-C-alkyl; Ris C-C-aryl, optionally substituted in one, two or three positions with a halogen, hydroxy group, R, R, C-C-alkylthio group, amino group, C-C-alkylamino group, etc. The rest of the values of the radicals are given in the claim.EFFECT : high efficiency of using said compounds.20 cl, 2 tbl