Immuno-Based Retargeted Endopeptidase Activity Assays

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The present specification discloses SNAP-25 immune response inducing compositions, methods of making a- SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the PI residue of the BoNT/A cleavage site scissile bond, ±-SNAP-25 antibodies that selectively bind to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, methods of detecting retargeted endopeptidase activity, and methods of detecting neutralizing ±-re-targeted endopeptidase antibodies.