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A process for the preparation of bicyclo[3.1.0]hexanols

2025-06-22 19:233790下载
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A process for the preparation of a compound of the formula (I) : which process comprises the intramolecular cyclopropanation of an epoxide of the formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium base, wherein R, R, R and Rare each hydrogen or C alkyl or R and R are linked to form a C cycloalkyl or C cycloalkenyl ring.


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