NANOPARTICLES COMPRISING A CORE OF AMORPHOUS RARE EARTH ELEMENT HYDROXIDE AND AN ORGANIC COATING

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The present invention relates to paramagnetic nanoparticles which may be used as contrast agents for visualizing or imaging biological material. Said nanoparicles comprise a core of amorphous rare earth element hydroxide, and an organic coating comprising silicon atoms and phosphorus atoms. Preferably, the coating comprises an oriented monolayer of one or more organo-oxysilane residue(s). A second silane, binding in between the larger organo-oxysilane, may be added in order to stabilize the coating. Methods for preparing said nanoparticles are also disclosed.