A temporal sequence of fluoroscopic images available for re-initialization Determination method (B (

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A determination method for reinitialization of a temporal sequence of fluoroscopic images of an examination region of an examination object is provided. The examination region comprises a vascular system including arteries and/or veins. An acquisition time is assigned to each of the images representing a given distribution of a substance in the examination region at the acquisition time. A computer receives the temporal sequence of the images, determines an evaluation image corresponding spatially on a pixel-by-pixel basis to the images, and calculates a differential value between a pixel of the evaluation image at a time and a pixel at a preceding time during a time characteristic of the sequence. A reinitialization of the temporal sequence of the images is performed at a specific time and thereafter the determination method is started over and/or repeated. The specific time is determined as a function of at least one previously calculated differential value.