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The invention relates to a method for reducing the number of bacterial germs in the production of milk and related substances used more lactose-freemore lactose-poor or immobilized enzymes is carried out in which an enzymatic lactose hydrolysis, wherein the required enzyme is bound to an insoluble carrier material for the hydrolysis and forms a immobilizate is, wherein the bond in particular beads or membranes or within porous systems is present, wherein the substrate added to a charge of immobilizate is to be hydrolysed, after reaction has taken place in a simple way from the product (cleavage products) separated and a reuse in a succession of further batches of the product life cycle to be hydrolysed in the context of a substrate or over a longer time period with each supplied in a flow-through reactor (Feed and bleed) is used to be hydrolyzed substrate. It is the purpose of the present invention, in a method to achieve a reduction in the number of bacteria on the type of immobilizate is would genericin accordance with-eat, wherein a multiple and economic re-usability is ensured the [...]. These, the chronologically successive method steps a) to e) achieved : a) When operated above a predetermined (K *) in the product (P) a border germ numbergerm-loaded is, (para) loaded with residual product (( (T + C) + p) *) for the disinfection immobilizate is from the product life cycle (Z) separated; b) from the...