Tolerance-induced targeted antibody production

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(57) Abstract : The present invention provides methods for directing the immune response of an animal towards immunologically weak or rare antigens such as tumor antigens. The methods combine subtractive immunization with hyperimmunization and result in the controlled or directed production of target-specific antibodies, helper T cells (CD4+-T lymphocytes) and cytotoxic T cells (CD8+-T lymphocytes). Also provided by the present invention are untransformed and transformed cell lines, and growth media ecessary to grow the untranstormed cell line in a difterentiated state. Monoclonal antibodies which react with different neoplastic cell lines and hybridomas producing such antibodies are also provided. Published : For two-letter codes and other abbreviations, refer without international search report and to be republished ance Notes on Codes and Abbreviations" appearing upon receipt of that report ning of each regular issue of the PCT Gazette.