System and method for predicting rare events

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Systems and methods are provided for predicting rare events, such as hospitalization events. Predictor sequences may be generated by example systems and methods. Further, the fitness of those sequences may be measured. Sequences may be refined and/or combined with other sequences to produce better sequences. Related sequences may have their relationship identified and associated with the respective sequences. Finally, the sequences may be used to create a predictive model designed to determine, based on a sequence of events related to a person, if a hospitalization event is likely to occur in a given timeframe. Other models may be constructed and used to predict other rare events, based on related event sequences.