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The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad re-peat domain in a stabilized .alpha.-helical structure (herein also referred to as SAH). The compositions are useful for treating and/or preventing viral infections. The invention is based, at least in part, on the result provided herein demonstrating that viral hydrocar-bon stapled alpha helical peptides display excellent proteolytic, acid, and thermal stability, restore the native alpha- helical struc-ture of the peptide, are highly effective in interfering with the viral fusogenic process, and possess superior pharmacokinetic prop-erties compared to the corresponding unmodified peptides.