METHODS OF USING CYTOKINE C17

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We have found that C17 protein stimulates the growth of endothelial and hematopoietic cells expressing the CD34 marker. In bone marrow and blood, rare populations of cells expressing CD34 are immature precursors for both hematopoietic and endothelial cells, including hematopoietic stem cells, endothelial progenitor cells and hemangioblasts. This finding makes C17 useful for promotion of angiogenesis and makes it a target for drugs for antiangiogenesis. Thus C17 specific molecules will be useful for treating tumors and leukemias, as well as for treating wounds to encourage healing.