Automatically detecting cells having nuclear and cytoplasmic densitometric features associated with

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(57) Abstract : A system and method for rapidly detecting cells (1) of interest using multi-dimensional, highly quantitative, nuclear and cytoplasmic densitometfic features (NDFs and CDFs) includes a flow optical tomogmphy (FOT) instrument capable of generating various optical projection images (or shadowgrams) containing accurate density information from a cell, a computer (40) and software to analyze and reconstruct the projection images into a multi-dimensional data set, and automated feature collection and object classifiers. The system and method are particularly useful in the early detection of cancers such as lung cancer using a bronchial specimen from sputum or cheek scrapings and cervical/ovarian cancer using a cervical scraping, and the system can be used to detect rare cells in specimens including blood. COMPUTER ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, (88) Date of publication of the international search report : SK, TR), OAPI patent (BF, B J, CF, CG, CI, CM, GA, GN, 4 September 2003 GQ, GW, ML, MR, NE, SN, TD, TG). For two-letter codes and other abbreviations, refer to the "GuidPublished : ance Notes on Codes andAbbreviations" appearing at the beginwith international search report ning of each regular issue of the PCT Gazette. before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments