NOVEL MUSCLE RELAXANT USING NEGATIVE CHARGE GOLD NANOPARTICLE WITH CHOLINE

文件类型：PDF文档
文件大小：894K
A drug having muscle relaxing effect can be prepared by binding negative charge gold nanoparticle having a size of 1.4nm fitted to a synaptic cleft to choline through an ionic bond, thereby inducing a gold-sulfur bond at Cys loop of an acetylcholine receptor in neuromuscular junction, and thus blocking the electric current induced in signal transduction from a nerve to a muscle, thereby blocking neuromuscular transmission chemically and physically. When the Reverse is administered after surgery, the gold-sulfur bond is broken due to the re-flow of the electric current, and thus the gold nanoparticle is again exited and metabolized into neuromuscular junction. Further, such muscle relaxing effect can be applied as an anticonvulsant.