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(57) Abstract : It is intended to provide a blood cell separation system whereby rare emb o-origin nuclear * I (N R B C), B N @ flN : , g, j , ... cells contained in the blood of a pregnant woman can be precisely separated and concentrated to conveniently give test specimens usable in prenatal chromosome/gene diagnosis. Namels; a blood cell separation system which comprises (1) a separation unit whereby anucleate erythrocytes, leukocytes and platelets are mainly eliminated from a blood specimen collected from a pregnant woman I to give a primarily separated specimen; (2) a secondary separation unit whereby anucleate erythrocytes and leukocytes remaining in the primarily separated specimen obtained by the above-described unit are eliminated by • FISH E using the sugar chain-lectin method to thereby give a secondly separated specimen having concentrated embryo nucleated cells; and (3) a sampling unit whereby the secondly separated specimen obtained by the secondarily separating unit is sampled. .MATERNAL BLOOD SAMPLE ..EMBRYO IMMATURE CELLS (NRBC), ANUCLEATE ERYTHROCYTES, GRANULOCYTES, LEUKOCYTES, PLATELETS, ETC. ..PRIMARILY Separating UNIT ..SPECIFIC GRAVITY CENTRIFDGATION ..FILTER SEPARATION ..SECONDLY SBPA gTING UNIT ..SUGAR CHAIN-LECTIN METHOD ..SAMPLING ..CENTRIFUGATION ..EMBRYO IMMATURE CELL TEST SAMPLE ..FISH METHOD ..GBNE SCREENING