Custom-made meganuclease and use thereof

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(57) Abstract : New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal, or plant comprising said polynucleotide equences, process for producing said rare cutting endonucleases and any use thereof, more particularly, for genetic engineering, antiviral therapy and gene therapy.