MICROCHIP-BASED DEVICES FOR CAPTURING CIRCULATING TUMOR CELLS AND METHODS OF THEIR USE

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In general, the invention provides devices and methods for capturing rare cells, e.g., CTCs from blood samples. The devices of the invention are capable of capturing large numbers of viable CTCs in a single step from whole blood without pre-dilution, pre-labeling, pre-fixation, or any other processing steps. The techniques described here and the broader application of microfluidic rare cell capture technology to cancer patients hold significant promise for identifying key biological determinants of blood-borne metastases, and for providing a robust platform aimed at early diagnosis and longitudinal monitoring of cancer.