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Substituted 5-aryl-2, 4-thiazolidinediones are potent agonists of PPAR, and a re therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia a nd hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR .alpha., .delta. and/or .gamma. mediated diseases , disorders and conditions.