| 简介 |
A paroxetine intermediate, a method for preparing the same, and uses thereof are provided. Specifically, the method includes : reacting a compound of formula I below with a compound of formula II in the presence of an organic base under the catalysis of a complex formed from a chiral amine oxide L and a rare-earth metal compound Ln(OTf)3 to prepare a compound of formula III below : wherein R1 is alkyl, phenyl or benzyl; R2, R3, R4 are each independently C1-C6 alkyl or C6-C10 aryl; the chiral amine oxide L has the following structure : wherein n=1, 2; and R=Ph—, 2, 6—Me2C6H3—, 2, 6—Et2C6H3—, 2, 6-iPr2C6H3—, Ph2CH—. |
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