| 简介 |
A diagnostic composition that include a diagnostically effective capture group that is chemically bonded to defined regions of a contact lens, where each diagnostically effective capture group on the contact lens binds tightly and in long-lived complexes to specific and rare biomarkers associated with a diseased state during a period when the contact lens is on the eyeball of the subject. Also provided are methods and kits useful for detecting the bound biomarker in the contact lens by using an enzyme coupled antibody that also binds to the biomarker on the contact lens and turns over a chromogenic or fluorogenic substrate whose insoluble product is recorded at the site of biomarker capture on the contact lens using a cell phone camera or related imaging device and calibrated and quantified using an associated software application to determine the level of the disease biomarker in the patient. |
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