| 简介 |
FIELD : pharmacology.
SUBSTANCE : set of reagents and a solution of sodium perrhenate, 188Re obtained from 188W/188Re generator is prepared. First, a set of lyophilized reagents is prepared, consisting of two vials of lyophilized reagents. Vial 1 contains lyophilized tin dichloride, dihydrate and stabiliser. Vial 2 contains a lyophilized neutralizing agent to adjust acidity. Radio pharmaceutical composition for radiosynovectomy is synthesized. First, a sodium perrhenate solution, 188Re, from 188W/188Re generator is obtained. For elution, an 0.9% isotonic sodium chloride solution for injection is used. Then 1.0 ml of sodium perrhenate solution 188Re, with a volume activity of 37 to 1850 MBq/ml is introduced into vial 1. The resulting suspension is stirred. Kept at the room temperature for 1 hour. Then 2.5 ml of 0.9% isotonic sodium chloride solution for injection is injected into vial 2 and stirred. After complete dissolution of the lyophilized agent, a syringe is used to remove all content from vial 2 and inject it into vial 1, the formed suspension is stirred, obtaining a radio pharmaceutical composition for radiosynovectomy ready for application, the pH value of the finished composition is 3.2-5.9, radiochemical purity exceeds 90%, output of labelled particles with dimensions of 2-10 µm is more than 80%. A radio pharmaceutical composition for radiosynovectomy is proposed as well.
EFFECT : homogeneous distribution of the radio pharmaceutical composition in the intra-articular space for 72 hours without causing an inflammatory reaction.
6 cl, 8 tbl, 3 ex |
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