客服热线:18202992950

PEPTIDE FOR ANTI-EBOLA VACCINE 发明申请

2023-03-01 3940 1180K 0

专利信息

申请日期 2025-07-23 申请号 WOIB15057709
公开(公告)号 WO2016059517A1 公开(公告)日 2016-04-21
公开国别 WO 申请人省市代码 全国
申请人 SPINOSA Jean Pierre; STRELNIKOV Evgeny; KANDUC Darja
简介 Based on the concept according to which protein immunogenicity more likely resides in unique/rare peptide sequences and aiming at defining epitopic peptides that might serve for therapeutic anti-Ebolavirus (EV) vaccines, a set of 45 EV proteomes was searched for peptide motifs unique to EVs and absent in human proteins. The search highlighted one peptide, LWQQWDR, that represent the molecular signature of the 45 EVs and is absent in the human proteome at the pentapeptide level. Synthetic oligopeptide constructs based on such unique viral fragment might be used for constructing synthetic oligopeptides for vaccine formulations, thus offering the possibility of hitting 1) multiple EV species/strains, 2) with high specificity and 3) without crossreactivity-associated adverse events. A rationale for constructing LWQQWDR-based synthetic oligopeptides is also described.


您还没有登录,请登录后查看下载地址


反对 0举报 0 收藏 0 打赏 0评论 0
下载排行
网站首页  |  关于我们  |  联系方式  |  使用协议  |  版权隐私  |  网站地图  |  排名推广  |  广告服务  |  积分换礼  |  网站留言  |  RSS订阅  |  违规举报  |  京ICP备2021025988号-4