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INHIBITORS OF AKT ACTIVITY 发明授权

2023-11-26 2090 1839K 0

专利信息

申请日期 2025-07-16 申请号 RU2012131115
公开(公告)号 RU2579513C2 公开(公告)日 2016-04-10
公开国别 RU 申请人省市代码 全国
申请人 OLMAK DISKAVERI LTD
简介 FIELD : chemistry.SUBSTANCE : invention relates to compounds of formula, where each Rand Ris independently selected from hydrogen, C-Calkyl, optionally substituted OH and OR, where Rrepresents C-Calkyl, or Rand Rtogether represent oxo or optionally C-Calkyl O-substituted oxime; W represents O, NR′ or CRR, where R′ represents either hydrogen, or C-Calkyl; X is either absent or represents CRR, where each R, R, Rand Rare independently selected from substituents, given for Rand R; Y and Z independently represent substituted or non-substituted nitrogen or carbon (substituents for which are given in i. 1 of the invention formula), or Y and Z together form optionally substituted pyrazolyl, imidazolyl, pyriminidyl, 1, 2, 4-triazolyl (substituents for which are given in i. 1 of the invention formula); Rand Rrepresent H; Rand Rrepresent H or Rand Rcan be combined with formation of C-Ccycloalkyl, optionally substituted with one or two substituents, selected from C-Calkyl and OH; Cy is selected from Calkyl(C-C)cycloalkyl, phenyl, pyridinyl and thienyl; m equals 0 or 1; Rrepresents F. the invention also relates to particular compounds, given in i. 1 of the invention formula, to pharmaceutical composition and method for treating malignant tumour.EFFECT : novel methods for Akt inhibition.19 cl, 1 dwg, 153 ex


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