申请日期 | 2025-07-12 | 申请号 | US13836469 |
公开(公告)号 | US8889855B2 | 公开(公告)日 | 2014-11-18 |
公开国别 | US | 申请人省市代码 | 全国 |
申请人 | Bio Thera Solutions Ltd Co | ||
简介 | Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods. |
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