| 申请日期 | 2025-07-18 | 申请号 | WOCN13001478 |
| 公开（公告）号 | WO2014094354A1 | 公开（公告）日 | 2014-06-26 |
| 公开国别 | WO | 申请人省市代码 | 全国 |
| 申请人 | BIO THERA SOLUTIONS LTD | ||
| 简介 | Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods. | ||
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