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MICROFLUIDIC DEVICE AND METHOD FOR DETECTING RARE CELLS 发明申请

2023-07-01 3360 1643K 0

专利信息

申请日期 2025-07-08 申请号 WOUS13067315
公开(公告)号 WO2014070776A1 公开(公告)日 2014-05-08
公开国别 WO 申请人省市代码 全国
申请人 THE REGENTS OF THE UNIVERSITY OF MICHIGAN
简介 A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.


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