| 简介 |
FIELD : chemistry.SUBSTANCE : invention describes novel azabiphenylaminobenzoic acid derivatives, having the chemical formula : , where Ris selected from a group consisting of hydrogen atoms, halogen atoms, C-alkyl, C-cycloalkyl and -CF, Ris selected from a group consisting of hydrogen atoms, halogen atoms and C-alkyl group, Ris -COOR, where Ris selected from a group consisting of a hydrogen atom and linear or branched C-alkyl groups, Ris selected from a group consisting of a hydrogen atom and C-alkyl group; Ris selected from a group consisting of a hydrogen atom and a phenyl group, Gis a group selected from N and CR, where Ris selected from a group consisting of hydrogen atoms, halogen atoms, C-alkyl, C-cycloalkyl, -CPand C-aryl group, Gis a group selected from : - a hydrogen atom, hydroxy group, halogen atom, C-cycloalkyl group, C-alkoxy group and -NRR, where Ris C-alkyl group and Ris selected from a group consisting of C-alkyl group and C-alkoxy-C-alkyl group, or Rand Rtogether with the nitrogen atom with which they are bonded, form a saturated 6-8-member heterocyclic ring optionally containing one oxygen atom as an additional heteroatom, -monocyclic or bicyclic 5-10-member heteroatomatic ring containing one or more nitrogen atoms which are optionally substituted with one or more halogen atoms, and a phenyl group which is optionally substituted with one or more substitutes selected from halogen atoms, C-alkyl, hydroxy group, C-alkoxy group, C-cycloalkyl, C-cycloalkoxy group, cyano group, -CF, -OCF, -CONRR, oxadiazolyl, and where Rand Rare independently selected from a hydrogen atom, a linear or branched C-alkyl group, C-cycloalkyl group, or Rand Rtogether with a nitrogen atom with which they are bonded form a group of formula : , where n equals 0-3; or Gtogether with Rform a non-aromatic C-carbocyclic group or a C-aryl group, and pharmaceutically acceptable and N oxides thereof. Also described are pharmaceutical compositions containing said compounds and use thereof in treatment as dehydroorotate dehydrogenase (DHODH) inhibitors.EFFECT : novel compounds which can be used as dehydroorotate dehydrogenase inhibitors are obtained and described.30 cl, 118 ex |
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