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Rare cell analysis using sample splitting and DNA tags 发明申请

2023-11-24 2780 2938K 0

专利信息

申请日期 2025-06-28 申请号 EP12180149
公开(公告)号 EP2589668A1 公开(公告)日 2013-05-08
公开国别 EP 申请人省市代码 全国
申请人 Verinata Health Inc; CELLective Dx Corporation; The General Hospital Corporation
简介 The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.


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