| 简介 |
The invention relates to the field of molecular biology, virology and medicine and concerns novel biologically active compounds, more specifically salts of carbamoyl phosphonic acid esters of the general formula given in the description. The novel compounds are capable of selectively inhibiting the production of human immunodeficiency virus and can therefore be considered for use in the field of medicine for the treatment of AIDS. The compounds are produced by adding an equimolar amount of ammonia, a corresponding amino compound or a hydroxide of an alkali metal or alkaline-earth metal to an acid form of a carbamoyl phosphonic acid ester. The resultant solutions of salts are boiled down to small volumes, from which spontaneous crystallization commences, and are left to stand at 4°С until crystallization ceases, whereupon the precipitates are filtered and dried in a vacuum. The target compound yield is 95-98%. The novel compounds inhibit the proliferation of HIV-1 in MT-4 lymphocyte cell cultures and are stable substances, thus facilitating the creation of drugs based thereon. |
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