| 简介 |
FIELD : medicine.SUBSTANCE : present invention refers to a boron-containing compound of formula : wherein R, R, Rand Rindependently mean -NO, halogen or a substitute presented by the following formulawherein the substitutes Y are independently found in an ortho-, meta- or para- position on a phenyl ring, and independently mean hydrogen or a substitute presented by formula : provided at least one of R, R, Rand Rmeans a substitute presented by formula (2) wherein Y is presented by formula (3); wherein : X means oxygen or sulphur; Rand Rare independently specified in hydrogen and C-Chydrocarbonyl; Z means a carborane cluster containing at least two carbon atoms and at least three boron atoms, or at least one carbon atom or at least five boron atoms in a frame structure; r means 0 or an integer within 1 to 20; a means an integer within 1 to 4; and also provided at least one of R, R, Rand Rmeans a substitute presented by -NOor halogen; and M means either two hydrogen ions, or a two-valence metal ion, a three-valence metal ion, a four-valence metal ion with a charge of the porphirine-metal complex formed by the three-valence or four-valence metal ion being neutralised by a corresponding number of counteranions, dianions. There are also presented a method for visualising a tumour and surrounding tissues, and a method for bimodal therapy of cancer.EFFECT : invention provides preparing carboranylporphyrines with a prolonged tumour time selectively targeted on tumour cells and destructing them with minimal involvement of healthy tissues.24 cl, 4 tbl, 12 ex |
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