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Method for improving cleavage of DNA by endonuclease sensitive to methylation 发明申请

2023-12-22 4940 3866K 0

专利信息

申请日期 2025-06-24 申请号 AU2011273097
公开(公告)号 AU2011273097A1 公开(公告)日 2013-01-17
公开国别 AU 申请人省市代码 全国
申请人 Cellectis
简介 (57) Abstract : The present invention concerns novel methods for improving cleavage of DNA by rare-cutting endonucleases, overcoming DNA modification constraints, particularly DNA methylation, thereby giving new tools for genome engineering, par- ticularly to increase the integration efficiency of a transgene into a genome at a predetermined location, including therapeutic ap- plications and cell line engineering. II Ill (88) Date of publication of the international search report : May 2012


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