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ANALYSIS OF CIRCULATING TUMOR CELLS, FRAGMENTS, AND DEBRIS 发明授权

2023-09-19 4710 410K 0

专利信息

申请日期 2025-07-10 申请号 EP02761478
公开(公告)号 EP1425294B2 公开(公告)日 2012-12-12
公开国别 EP 申请人省市代码 全国
申请人 Veridex LLC
简介 The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter3 fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage : in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.


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