| 申请日期 | 2026-04-22 | 申请号 | WOUS11066810 |
| 公开（公告）号 | WO2012088402A1 | 公开（公告）日 | 2012-06-28 |
| 公开国别 | WO | 申请人省市代码 | 全国 |
| 申请人 | THE SCRIPPS RESEARCH INSTITUTE; BOHN Laura M; MICALIZIO Glenn C | ||
| 简介 | The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example, (+/- )-, (+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain. | ||
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