| 简介 |
Novel benzothiazin derivatives of formula (I) and their use as antibacterial agents in infectious diseases caused by bacteria, especially tuberculosis (TB) and leprosy caused by mycobacteria, wherein R and Rare, independently each from other, NO, CN, CONRR, COOR, CHO, halogen, NRR, SONRR, SR, OCF, mono-, di or trifluoromethyl; R and R are, independently each from other, H, a saturated or unsaturated, linear or branched aliphatic radical having 1-7 chain members, cycloalkyl having 3-6 carbon atoms, benzyl, SR, OR; R and R are, independently each from other, a saturated or unsaturated, halogenated or unhalogenated, linear or branched aliphatic radical having 1-8 chain members, cycloalkyl having 3-6 carbon atoms, phenyl, or R and R together represent a bivalent radical -(CR )m-, or R and R together represent bivalent radicals : formula (II) or (III), wherein m is 1-4, or represent bivalent radicals a saturated or unsaturated mono or polyheterocycles with heteroatoms N, S, O and substituted by (R)x, wherein x is 1-4. |
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