| 简介 |
The invention relates to the areas of the materials sciences and to medicine, and relates to an agent that can be used as a contrast medium for the localization of cancer cells, for example. The object of the present invention is to provide an agent which sensitively and selectively recognizes the location and type of molecules or cells to be examined. The object is accomplished through an agent comprising at least bio-shuttle molecules to which endohedral fullerenes are coupled by way of peptide-based molecules, wherein the endohedral fullerenes are hydrophobic and correspond to the formula : A3-χMxZ@C2n, where x = 0 to 3, n ≥ 34, A is a rare earth and/or a transuranic element, M is a metal, Z is a non-metal and C is carbon. The object is further accomplished through a method in which hydrophobic, endohedral fullerenes are coupled to bio-shuttle molecules by way of an irreversible Diels-Alder reaction that has an inverse electron demand (DARιnv). |
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