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MODULAR MONOLAYER COATINGS FOR SELECTIVE ATTACHMENT OF NANOPARTICLES TO BIOMOLECULES 发明申请

2023-01-21 1950 1438K 0

专利信息

申请日期 2025-07-10 申请号 US12489242
公开(公告)号 US20100034742A1 公开(公告)日 2010-02-11
公开国别 US 申请人省市代码 全国
申请人 Jeffrey Schwartz; Christopher A Traina; Thomas J Dennes
简介 Nanoparticles are functionalized for use as bio-imaging probes using a novel, modular approach. Particle surface modification is based on a phosphonate monolayer platform on which was built a multi-segmented, multi-functional film : the first segment provided hydrolytic stability, the second aqueous suspendability, and the third, selectivity for cell attachment. In vitro imaging experiments visualized nanoparticle—cell surface binding. Peptide-derivatized nano-particles were not displaced from cells by soluble peptide. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.


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