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Method of making a homogeneous preparation of hematopoietic stem cells 其他

2023-10-18 4700 17K 0

专利信息

申请日期 2025-07-18 申请号 AU2002340542
公开(公告)号 AU2002340542A8 公开(公告)日 2008-01-17
公开国别 AU 申请人省市代码 全国
申请人 THE JOHNS HOPKINS UNIVERSITY
简介 Purification of rare Hematopoietic Stem Cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts are the gold standard for demonstrating self renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients. During the homing, CD34 and SCA-1 expression increases uniquely on cells that home to marrow. These adult bone marrow cells have tremendous differentiative capacity as they can also differentiate into epithelial cells of the liver, lung, GI tract, and skin. This finding may contribute to clinical treatment of genetic disease or tissue repair.


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