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RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS 发明申请

2023-09-04 1260 3215K 0

专利信息

申请日期 2025-07-12 申请号 WOUS07071256
公开(公告)号 WO2007147079A2 公开(公告)日 2007-12-21
公开国别 WO 申请人省市代码 全国
申请人 LIVING MICROSYSTEMS INC; CELLPOINT DIAGNOSTICS INC; THE GENERAL HOSPITAL CORPORATION; SHOEMAKER Daniel; FUCHS Martin; KRUEGER Neil X; TONER Mehmet; GRAY Darren; KAPUR Ravi; WANG Zihua
简介 The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.


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