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Fluorescent label compounds 发明授权

2023-07-17 3380 1815K 0

专利信息

申请日期 2025-08-03 申请号 US10506242
公开(公告)号 US7465747B2 公开(公告)日 2008-12-16
公开国别 US 申请人省市代码 全国
申请人 Kazuko Matsumoto; Jingli Yuan; Guilan Wang; Mingqian Tan
简介 It is intended to provide novel labeling reagents characterized by having a group capable of binding to a substance to be labeled (for example, a biological substance, a physiologically active substance, etc.), easily forming a complex together with a rare earth ion, the complex being stable in an aqueous solution, and having a sufficient fluorescence intensity and a long fluorescence life time regardless of buffer types; complexes composed of the above labeling reagent with a rare earth ion; fluorescence labels containing the above complex; a fluorescence assay method using the above fluorescent label; etc. Namely, labeling reagents comprising a compound having a 2, 2′ : 6′, 2″-tripyridine skeleton or a 2, 6-dipyrazolopyridine skeleton and having a group capable of binding to a substance to be labeled (for example, a biological substance, a physiologically active substance, etc.) and a group capable of forming a complex together with a rare earth ion; complexes composed of the above labeling reagent with a rare earth ion; fluorescence labels containing the above complex; a fluorescence labeling method using the above complex as a label; and a fluorescence assay method using the above fluorescent label.


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