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The metal used for the metal production and oncocyte deflection rolldeflection roll drug to suppress 发明申请

2023-10-19 3470 376K 0

专利信息

申请日期 2025-07-12 申请号 JP2008531511
公开(公告)号 JP2009511432A 公开(公告)日 2009-03-19
公开国别 JP 申请人省市代码 全国
申请人 Institute of High Energy Physics Chinese Academy of Sciences508085682
简介 This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C 2m (OH) x , wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C 2m O x H y . Comparing to the clinical anticancer drugs such as Pacilitaxel, Cyclophusphamide, and Cisplatin, metallofullerol of M@C 2m (OH) x or M@C 2m O x H y has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility.


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