| 简介 |
The present invention provides a pharmaceutical composition comprising a therapeutically amount of nicotinic acid and a nicotinic acid compound or mixtures thereof in a sustained release form and a therapeutically amount of a HMG-CoA reductase inhibitor in a fast release form which can optimally treat hyperlipidemia and arteriosclerosis by minimizing the interaction of two drugs. The pharmaceutical composition of the present invention comprising a coated two- layer tablet a) one sustained release layer containing nicotinic acid and a nicotinic acid compound or mixtures thereof, together with a sustained release polymer and b) another fast release layer containing a HMG-CoA reductase inhibitor, a film- or layer- forming agent, a re- crystallization inhibitor and a plasticizer, can minimize the interaction of the two drugs via controlled release profile and treat optimally hyperlipidemia and arteriosclerosis. |
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